BACKGROUND/AIMS The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition. METHODS We evaluated the genotypic frequencies of COX-2-765...

A total of 129 clinical isolates of Mycobacterium tuberculosis representing 91 patients were typed by a combination of direct-repeat (DR)-based spoligotyping and an inter-IS6110-PGRS (polymorphic GC-rich region)-PCR, also designated double-repetitive-element PCR (DRE-PCR). During the first phase of this investigation, 72 clinical strains representing 52 patients were initially typed by IS6110-r...

Introduction: Gastric cancer (GC) is one of the leading causes cancer-related decimations worldwide. The gastric infection at both stomach and duodenum with Helicobacter pylori inflammation by tumor necrosis factor-alpha (TNF-?). aim study was to associate evaluate three TNF-? gene polymorphisms positions ?308 G/A, ?238 ?857 C/T risk GC. Methods: A total 156 individuals (consecutively diagnosed...

BACKGROUND Chronic inflammation has been regarded as an important mechanism in carcinogenesis. Inflammation-associated genetic variants have been highly associated with cancer risk. Polymorphisms in the gene cyclooxygenase-2 (COX-2), a pro-inflammation factor, have been suggested to alter the risk of multiple tumors, but the findings of various studies are not consistent. METHODS A literature...

OBJECTIVES Published data on the association between Interleukin-8-251A/T polymorphism and gastric cancer (GC) risk are inconclusive. Thus, we conducted a meta-analysis to evaluate the relationship between cyclin D1 G870A polymorphism and GC risk. METHODS We searched PubMed, EMBASE, Web of science and the Cochrane Library up to July 12, 2015 for relevant studies. Odds ratios (ORs) and 95% con...

INTRODUCTION Helicobacter pylori cause damage to gastric epithelial cells and alterations in the p53 gene that lead to cancer development. This study aimed to determine the correlation of p53 expression with H. pylori using immunohistochemistry, RFLP-PCR, and histopathology. METHODOLOGY Gastric biopsy samples from gastric cancer (GC) (n = 54) and gastritis (n = 31) patients were examined for ...

Aim The aim of this study was to find the relationship between rs1799964 in TNF-α gene as well as rs1051208 of RAF1 gene SNPs on GC in an Iranian population. Background Gastric cancer (GC) is the second leading cause of cancer-related death worldwide after lung cancer. Tumor necrosis factor (TNF) is one of the most important factors in the pathogenesis of this cancer. Single nucleotide polymo...

Objective: Our study examines nuclear factor kappa B (NF-қB) and cyclooxygenase-2 (COX-2) polymorphisms in the most common gynecological cancer type, endometrial cancer, relationship between disease parameters these polymorphisms.
 Methods: In our patient group; while 109 patients were examined treated Department of Gynecology Obstetrics, Istanbul Medical Faculty, 106 healthy women without...